Circadian disruption in mice through chronic jet lag-like conditions modulates molecular profiles of cancer in nucleus accumbens and prefrontal cortex

Abstract Biological rhythms regulate physiological activities. Shiftwork disrupts normal circadian and may increase the risk of cancer through unknown mechanisms. To mimic environmental light/dark changes encountered by shift workers, a protocol called ‘chronic jet lag (CJL)’ induced repeatedly shifting light–dark cycles has been used. Here, we subjected mice to CJL advancing cycle 6 h every 2 days, conducted RNA sequencing analyze expression profile molecular signature in brain areas prefrontal cortex nucleus accumbens. We also performed positron emission tomography (PET) imaging monitor related glucose metabolism brain. Our results reveal systematic reprogramming gene associated with cancer-related pathways metabolic PET indicates that uptake level was significantly reduced whole as well individual regions. Moreover, qPCR analysis describes levels genes were altered Overall, these suggest link CJL-mediated risk, generate hypotheses on how increases susceptibility cancer.